The Dual Role of Calcium as Messenger and Stressor in Cell Damage, Death, and Survival. (15th March 2010)

• Record Type: Journal Article
• Authors: Cerella, Claudia; Diederich, Marc; Ghibelli, Lina
• Other Names: Fulda Simone Academic Editor.
• Is Part Of: International journal of cell biology. Volume 2010(2010)
• Publication Date: 2010-03-15
• Subjects: Cytology -- Periodicals; Cell Biology; Cytology; Periodicals; Electronic journals -- Sciences; Electronic journals -- Biology; Periodicals; 571.6
• DOI: 10.1155/2010/546163
• Languages: English
• ISSNs: 1687-8876

Abstract

Abstract : Ca 2 + is an important second messenger participating in many cellular activities; when physicochemical insults deregulate its delicate homeostasis, it acts as an intrinsic stressor, producing/increasing cell damage. Damage elicits both repair and death responses; intriguingly, in those responsesCa 2 + also participates as second messenger. This delineates a dual role forCa 2 + in cell stress, making difficult to separate the different and multiple mechanisms required forCa 2 + -mediated control of cell survival and apoptosis. Here we attempt to disentangle the two scenarios, examining on the one side, the events implicated in deregulatedCa 2 + toxicity and the mechanisms through which this elicits reparative or death pathways; on the other, reviewing the role ofCa 2 + as a messenger in the transduction of these same signaling events.