Detection of Immunoglobulin E with a Graphene-Based Field-Effect Transistor Aptasensor. (22nd July 2018)

• Record Type: Journal Article
• Authors: Lan, Yi; Farid, Sidra; Meshik, Xenia; Xu, Ke; Choi, Min; Ranginwala, Saadia; Wang, Yung Yu; Burke, Peter; Dutta, Mitra; Stroscio, Michael A.
• Other Names: Neitzert Heinz C. Academic Editor.
• Is Part Of: Journal of sensors. Volume 2018(2018)
• Publication Date: 2018-07-22
• Subjects: Detectors -- Periodicals; 681.205
• DOI: 10.1155/2018/3019259
• Languages: English
• ISSNs: 1687-725X

Abstract

Abstract : DNA aptamers have the ability to bind to target molecules with high selectivity and therefore have a wide range of clinical applications. Herein, a graphene substrate functionalized with a DNA aptamer is used to sense immunoglobulin E. The graphene serves as the conductive substrate in this field-effect-transistor-like (FET-like) structure. A voltage probe in an electrolyte is used to sense the presence of IgE as a result of the changes in the charge distribution that occur when an IgE molecule binds to the IgE DNA-based aptamer. Because IgE is an antibody associated with allergic reactions and immune deficiency-related diseases, its detection is of utmost importance for biomedical applications.