AgI‐Induced Switching of DNA Binding Modes via Formation of a Supramolecular Metallacycle. Issue 15 (19th February 2018)

• Record Type: Journal Article
• Authors: Basak, Shibaji; Léon, J. Christian; Ferranco, Annaleizle; Sharma, Renu; Hebenbrock, Marian; Lough, Alan; Müller, Jens; Kraatz, Heinz‐Bernhard
• Is Part Of: Chemistry. Volume 24:Issue 15(2018)
• Page Start: 3729
• Page End: 3732
• Publication Date: 2018-02-19
• Subjects: binding -- DNA -- silver -- supramolecular complex -- spectroscopy; Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201800440
• Languages: English
• ISSNs: 0947-6539

Abstract

Abstract: The histidine derivative L1 of the DNA intercalator naphthalenediimide (NDI) forms a triangular Ag I complex (C2). The interactions of L1 and of C2 with DNA were studied by circular dichroism (CD) and UV/Vis spectroscopy and by viscosity studies. Different binding modes were observed for L1 and for C2, as the Ag I complex C2 is too large in size to act as an intercalator. If Ag I is added to the NDI molecule that is already intercalated into a duplex, higher order complexes are formed within the DNA duplex and cause disruptions in the helical duplex structure, which leads to a significant decrease in the characteristic CD features of B‐DNA. Thus, via addition of a metal we show how a classic and well‐known organic intercalator unit can be turned into a partial metallo insertor. We also show how electrochemical impedance spectroscopy (EIS) can be used to probe DNA binding modes on DNA films that are immobilized on gold surfaces. Abstract : Supra with silver : A histidine‐linked NDI ligand formed a triangular metallacycle in presence of Ag I . The ligand has been used as a DNA intercalator, which transforms into a metallo‐insertor.