Acute Childhood Cardiorenal Syndrome and Impact of Cardiovascular Morbidity on Survival. (18th May 2011)

• Record Type: Journal Article
• Authors: Olowu, Wasiu A.
• Other Names: Rastogi Anjay Academic Editor.
• Is Part Of: International journal of nephrology. Volume 2011(2011)
• Publication Date: 2011-05-18
• Subjects: Nephrology -- Periodicals; Nephrology; Kidney Diseases; Nephrology; Periodicals; Periodicals; Fulltext; Internet Resources; Electronic journals; 616.61
• DOI: 10.4061/2011/412495
• Languages: English
• ISSNs: 2090-214X

Abstract

Abstract : Cardiorenal syndrome (CRS) clinical types, prevalence, aetiology, and acute cardiovascular morbidity impact on the outcome of acute kidney function perturbation were determined. Forty-seven of 101 (46.53%) patients with perturbed kidney function had CRS. Types 3 and 5 CRS were found in 10 and 37 patients, respectively. Type 3 CRS was due to acute glomerulonephritis (AGN;n = 7 ), captopril (n = 1 ), frusemide (n = 1 ), and hypovolaemia (n = 1 ). Malaria-associated haemoglobinuria (n = 20 ), septicaemia (n = 11 ), lupus nephritis (n = 3 ), tumour lysis syndrome (n = 2 ), and acute lymphoblastic leukaemia (n = 1 ) caused Type 5 CRS. The cumulative mortality in hypertensive CRS was similar to nonhypertensive CRS (51.4% versus 40.9%;P = .119 ). Mortality in CRS and non-CRS was similar (45.7% versus 24.5%;P = .053 ). Type 5 survived better than type 3 CRS (66.7% versus 12.5%;P = .001 ). Risk factors for mortality were Type 3 CRS (P = .001 ), AGN-associated CRS (P = .023 ), dialysis requiring CRS (P = .008 ), and heart failure due to causes other than anaemia (P = .003 ). All-cause-mortality was 34.2%. Preventive measures aimed at the preventable CRS aetiologies might be critical to reducing its prevalence.