B-Type Natriuretic Peptide in the Critically Ill with Acute Kidney Injury. (31st May 2011)

• Record Type: Journal Article
• Authors: de Cal, Massimo; Haapio, Mikko; Cruz, Dinna N.; Lentini, Paolo; House, Andrew A.; Bobek, Ilona; Virzì, Grazia M.; Corradi, Valentina; Basso, Flavio; Piccinni, Pasquale; D'Angelo, Angela; Chang, Jamie W.; Rosner, Mitchell H.; Ronco, Claudio
• Other Names: Rastogi Anjay Academic Editor.
• Is Part Of: International journal of nephrology. Volume 2011(2011)
• Publication Date: 2011-05-31
• Subjects: Nephrology -- Periodicals; Nephrology; Kidney Diseases; Nephrology; Periodicals; Periodicals; Fulltext; Internet Resources; Electronic journals; 616.61
• DOI: 10.4061/2011/951629
• Languages: English
• ISSNs: 2090-214X

Abstract

Abstract : Introduction . Acute kidney injury (AKI) is common in the intensive care unit (ICU) and associated with poor outcome. Plasma B-type natriuretic peptide (BNP) is a biomarker related to myocardial overload, and is elevated in some ICU patients. There is a high prevalence of both cardiac and renal dysfunction in ICU patients. Aims . To investigate whether plasma BNP levels in the first 48 hours were associated with AKI in ICU patients. Methods . We studied a cohort of 34 consecutive ICU patients. Primary outcome was presence of AKI on presentation, or during ICU stay. Results . For patients with AKI on presentation, BNP was statistically higher at 24 and 48 hours than No-AKI patients (865 versus 148 pg/mL; 1380 versus 131 pg/mL). For patients developing AKI during 48 hours, BNP was statistically higher at 0, 24 and 48 hours than No-AKI patients (510 versus 197 pg/mL; 552 versus 124 pg/mL; 949 versus 104 pg/mL). Conclusion . Critically ill patients with AKI on presentation or during ICU stay have higher levels of the cardiac biomarker BNP relative to No-AKI patients. Elevated levels of plasma BNP may help identify patients with elevated risk of AKI in the ICU setting. The mechanism for this cardiorenal connection requires further investigation.