TBAI/K2S2O8 Initiated Radical Cyclization to Synthesize β‐ Arylsulfonyl Naphthalenes from Homopropargylic Alcohols and Sulfonyl Hydrazides. Issue 18 (1st August 2017)

• Record Type: Journal Article
• Authors: Yang, Xiaodong; Zhao, Lianbiao; Yuan, Bingxiang; Qi, Zhenjie; Yan, Rulong
• Is Part Of: Advanced synthesis & catalysis. Volume 359:Issue 18(2017)
• Page Start: 3248
• Page End: 3253
• Publication Date: 2017-08-01
• Subjects: β-arylsulfonyl naphthalenes -- homopropargylic alcohols -- sulfonyl hydrazides; Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.201700634
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: A metal‐free radical addition method for the synthesis of β ‐arylsulfonyl naphthalenes with homopropargylic alcohols and sulfonyl hydrazides has been developed. In this reaction, sulfonyl hydrazide is employed as the source of sulfonyl radical to produce the desired sulfone directly. There is the first example for homopropargylic alcohol through direct intramolecular addition of vinyl radical to arenes with sulfonyl radical, which is initiated by the TBAI/K2 S2 O8 reaction system and generates the desired products in moderate yields. Abstract :