Copper‐Catalyzed Aminodifluoroalkylation of Alkenes with α‐Bromodifluoroacetamides: Synthesis of 3, 3‐Difluoropyrrolidin‐2‐ones. Issue 18 (26th July 2017)

• Record Type: Journal Article
• Authors: Lv, Yunhe; Pu, Weiya; Wang, Qingqing; Chen, Qian; Niu, Jiejie; Zhang, Qian
• Is Part Of: Advanced synthesis & catalysis. Volume 359:Issue 18(2017)
• Page Start: 3114
• Page End: 3119
• Publication Date: 2017-07-26
• Subjects: Alkenes -- copper -- radical reactions -- aminodifluoroalkylation -- fluorinated nitrogen-containing heterocycles; Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.201700559
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: Copper‐catalyzed external‐oxidant‐free regioselective aminodifluoroalkylation of alkenes with readily available α‐bromodifluoroacetamides was realized. This reaction exhibits good functional group tolerance with respect to alkenes and α‐bromodifluoroacetamides in affording 3, 3‐difluoropyrrolidin‐2‐ones. A mechanism involving copper‐catalyzed generation of a difluoroalkyl radical is proposed. Abstract :