Knitted Silk Fibroin‐Reinforced Bead‐on‐String Electrospun Fibers for Sustained Drug Delivery Against Colon Cancer. Issue 5 (15th April 2018)

• Record Type: Journal Article
• Authors: Ma, Panpan; Gou, Shuangquan; Wang, Min; Chen, Jiucun; Hu, Wei; Xiao, Bo
• Is Part Of: Macromolecular materials and engineering. Volume 303:Issue 5(2018)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2018-04-15
• Subjects: bead‐on‐string -- biofibers -- colon cancer -- localized chemotherapy -- silk fibroin; Plastics -- Periodicals; Polymers -- Periodicals; Polymerization -- Periodicals; 547.705
• DOI: 10.1002/mame.201700666
• Languages: English
• ISSNs: 1438-7492

Abstract

Abstract: Bead‐on‐string electrospun fibers containing camptothecin (CPT) are fabricated on the surface of knitted silk fibroin (SF) meshes. Microscopic characterization reveals that the bead‐on‐string structure is prepared successfully and CPT is mainly located within the beaded structure. Interestingly, the CPT‐loaded beaded SF mesh (CPT‐SF mesh) has excellent mechanical properties. More importantly, it is able to perform a sustained CPT release without burst release. In vitro cytotoxicity tests further indicate that the CPT‐SF mesh shows much stronger anticolon cancer activity in comparison with SF meshes and beaded SF meshes. Hence, the CPT‐SF mesh has great potential as a promising local drug delivery system for colon cancer treatment. Abstract : Camptothecin (CPT)‐loaded bead‐on‐string electrospun fibers are produced on the surface of knitted silk fibroin (SF) mesh. The resultant SF‐CPT meshes exhibit strong mechanical properties, sustained CPT release profiles without burst release effect, and excellent anticolon cancer activity.