Zinc acetate-mediated regioselective N-acylation of 1, 3-disubstituted selenoureas. (1st June 2018)

• Record Type: Journal Article
• Authors: Li, Xue; Gan, Bin; Peng, Zhixiang; Mi, Zhisheng; Xie, Yuanyuan
• Is Part Of: Journal of chemical research. Volume 42:Number 5(2018)
• Page Start: 251
• Page End: 254
• Publication Date: 2018-06-01
• Subjects: Chemistry -- Research -- Periodicals; Chemistry -- Periodicals; 540.5
• DOI: 10.3184/174751918X15260514562361
• Languages: English
• ISSNs: 1747-5198

Abstract

N-acetylureas were synthesised regioselectively from 1, 3-disubstituted selenoureas and zinc acetate. Regioselectivity was dependent on the pKa of the amine attached to the selenourea and occurred towards the amine with the lower pKa. The approach provided a simple, mild and efficient way to construct various N-acetylureas regioselectively in moderate to good yields (53–88%). A plausible mechanism was proposed for the formation of N-acetylureas.