A simple green protocol for the synthesis of ethyl 3-amino-1-aryl-1H-benzo[f] chromene-2-carboxylates in aqueous media. (1st August 2017)

• Record Type: Journal Article
• Authors: Qian, Siran; Li, Mingjie; Liu, Jiaming; Wang, Cunde
• Is Part Of: Journal of chemical research. Volume 41:Number 8(2017)
• Page Start: 487
• Page End: 490
• Publication Date: 2017-08-01
• Subjects: Chemistry -- Research -- Periodicals; Chemistry -- Periodicals; 540.5
• DOI: 10.3184/174751917X15016663252830
• Languages: English
• ISSNs: 1747-5198

Abstract

An eco-friendly and efficient straightforward method has been developed for the synthesis of ethyl 3-amino-1-aryl-1H-benzo[f]chromene-2-carboxylate derivatives via 1, 4-diazabicyclo[2.2.2]octane (DABCO)-catalysed cyclisation of β-naphthol and 3-aryl-2-cyanoacrylates using water as a green solvent. All products precipitated from the reaction mixture and were isolated by simple filtration. No further workup nor purification was necessary. The structure of ethyl 3-amino-1-aryl-1H-benzo[f]chromene-2-carboxylate was further confirmed by X-ray single crystal analysis.