Synthesis, crystal structure and antitumour activity of 3-amino-N-(5-fluoro-2-methylphenyl)-4-morpholino-1H-indazole-1-carboxamide. (1st November 2017)

• Record Type: Journal Article
• Authors: Hao, Xue-chen; Lu, Jiu-fu; Chen, Ye; Wang, Yang; Ding, Shi; Liu, Ju
• Is Part Of: Journal of chemical research. Volume 41:Number 11(2017)
• Page Start: 624
• Page End: 626
• Publication Date: 2017-11-01
• Subjects: Chemistry -- Research -- Periodicals; Chemistry -- Periodicals; 540.5
• DOI: 10.3184/174751917X15065183733178
• Languages: English
• ISSNs: 1747-5198

Abstract

Compound 3-amino-N-(5-fluoro-2-methylphenyl)-4-morpholino-1H-indazole-1-carboxamide has been synthesised by condensation of 4-fluoro-2-isocyanato-1-methylbenzene with 4-morpholino-1H-indazol-3-amine, which was prepared from 2, 6-difluorobenzonitrile by amination with morpholine and then cyclisation with hydrazine hydrate. The crystal structure of the title compound was determined. In addition, the compound inhibits proliferation of some cancer cell lines.