Breast Cancer Profile among Patients with a History of Chemoprevention. (18th December 2016)

• Record Type: Journal Article
• Authors: Schnabel, Freya R.; Pivo, Sarah; Chun, Jennifer; Schwartz, Shira; Refinetti, Ana Paula; Axelrod, Deborah; Guth, Amber
• Other Names: Semiglazov Vladimir F. Academic Editor.
• Is Part Of: International journal of breast cancer. Volume 2016(2016)
• Publication Date: 2016-12-18
• Subjects: Breast -- Cancer -- Periodicals; Periodicals; Breast Neoplasms; Breast -- Cancer; Periodicals; Periodicals; 616.99449
• DOI: 10.1155/2016/9216375
• Languages: English
• ISSNs: 2090-3170

Abstract

Abstract : Purpose . This study identifies women with breast cancer who utilized chemoprevention agents prior to diagnosis and describes their patterns of disease. Methods . Our database was queried retrospectively for patients with breast cancer who reported prior use of chemoprevention. Patients were divided into primary (no history of breast cancer) and secondary (previous history of breast cancer) groups and compared to patients who never took chemoprevention. Results . 135 (6%) of 2430 women used chemoprevention. In the primary chemoprevention group ( n = 18, 1%), 39% had completed >5 years of treatment, and fully 50% were on treatment at time of diagnosis. These patients were overwhelmingly diagnosed with ER/PR positive cancers (88%/65%) and were diagnosed with equal percentages (44%) of IDC and DCIS. 117 (87%) used secondary chemoprevention. Patients in this group were diagnosed with earlier stage disease and had lower rates of ER/PR-positivity (73%/65%) than the nonchemoprevention group (84%/72%). In the secondary group, 24% were on chemoprevention at time of diagnosis; 73% had completed >5 years of treatment. Conclusions . The majority of patients who used primary chemoprevention had not completed treatment prior to diagnosis, suggesting that the timing of initiation and compliance to prevention strategies are important in defining the pattern of disease in these patients.