Design, Synthesis, and Analysis of Minor Groove Binder Pyrrolepolyamide-2′-Deoxyguanosine Hybrids. (22nd December 2009)

• Record Type: Journal Article
• Authors: Kawashima, Etsuko; Ohba, Yusuke; Terui, Yusuke; Kamaike, Kazuo
• Other Names: Sekine Mitsuo Academic Editor.
• Is Part Of: Journal of nucleic acids. Volume 2010(2010)
• Publication Date: 2009-12-22
• Subjects: Nucleic acids -- Periodicals; 572.805
• DOI: 10.4061/2010/235240
• Languages: English
• ISSNs: 2090-0201

Abstract

Abstract : Pyrrolepolyamide-2 ′ -deoxyguanosine hybrids (Hybrid2 and Hybrid3 ) incorporating the 3-aminopropionyl or 3-aminopropyl linker were designed and synthesized on the basis of previously reported results of a pyrrolepolyamide-adenosine hybrid (Hybrid1 ). Evaluation of the DNA binding sequence selectivity of pyrrolepolyamide-2 ′ -deoxyguanosine hybrids was performed by CD spectral andT m analyses. It was shown that Hybrid3 possessed greater binding specificity than distamycin A, Hybrid1 and Hybrid2 .