The Effect of Mitochondrial Dysfunction on Cytosolic Nucleotide Metabolism. (4th August 2010)

• Record Type: Journal Article
• Authors: Desler, Claus; Lykke, Anne; Rasmussen, Lene Juel
• Other Names: Basu Ashis Academic Editor.
• Is Part Of: Journal of nucleic acids. Volume 2010(2010)
• Publication Date: 2010-08-04
• Subjects: Nucleic acids -- Periodicals; 572.805
• DOI: 10.4061/2010/701518
• Languages: English
• ISSNs: 2090-0201

Abstract

Abstract : Several enzymes of the metabolic pathways responsible for metabolism of cytosolic ribonucleotides and deoxyribonucleotides are located in mitochondria. Studies described in this paper suggest dysfunction of the mitochondria to affect these metabolic pathways and limit the available levels of cytosolic ribonucleotides and deoxyribonucleotides, which in turn can result in aberrant RNA and DNA synthesis. Mitochondrial dysfunction has been linked to genomic instability, and it is possible that the limiting effect of mitochondrial dysfunction on the levels of nucleotides and resulting aberrant RNA and DNA synthesis in part can be responsible for this link. This paper summarizes the parts of the metabolic pathways responsible for nucleotide metabolism that can be affected by mitochondrial dysfunction.