Previously Unreported Chromosomal Aberrations of t(3;3)(q29;q23), t(4;11)(q21;q23), and t(11;18)(q10;q10) in a Patient with Accelerated Phase Ph+ CML. (22nd February 2014)

• Record Type: Journal Article
• Authors: Aydin, Cigdem; Cetin, Zafer; Salim, Ozan; Yucel, Orhan Kemal; Undar, Levent; Berker Karauzum, Sibel
• Other Names: Bunyan D. J. Academic Editor.; Cotter P. D. Academic Editor.; Sazci A. Academic Editor.
• Is Part Of: Case reports in genetics. Volume 2014(2014)
• Publication Date: 2014-02-22
• Subjects: Genetics -- Periodicals; Genetics -- Case studies -- Periodicals; Genetics; Genetic Phenomena; Genetics; Periodicals; Case studies; Periodicals; Case Reports; Fulltext; Internet Resources; Periodicals; 576.5
• DOI: 10.1155/2014/582016
• Languages: English
• ISSNs: 2090-6544

Abstract

Abstract : Chronic myelogenous leukemia (CML) is a clonal hematological disorder, which is characterized by the presence of the classical or variant Philadelphia translocations. During the progression to blastic phase of the disease secondary chromosomal abnormalities may emerge. Such secondary chromosomal abnormalities are nonrandom, the more frequent ones being trisomy 8 and 19, supernumerary i(17q), and extra Philadelphia chromosomes. Furthermore, a minor percentage of the patients may acquire different secondary chromosomal abnormalities including translocations between other chromosomes. We report here a patient with Ph+ CML presenting secondary chromosomal abnormalities including t(4;11)(q21;q23), t(3;3)(q29;q23) and t(11;18)(q10;q10) during the course of CML progression.