A Time to Pause and Reflect: When a Patient with Autoimmune Hepatitis Stops Responding to Corticosteroids. (25th December 2016)

• Record Type: Journal Article
• Authors: Tsang, Lewis; Fadia, Mitali; Chitturi, Shivakumar
• Other Names: Altintas Engin Academic Editor.
• Is Part Of: Case reports in gastrointestinal medicine. Volume 2016(2016)
• Publication Date: 2016-12-25
• Subjects: Gastroenterology -- Case studies -- Periodicals; Digestive organs -- Diseases -- Periodicals; Gastroenterology; Gastrointestinal Diseases; Digestive organs -- Diseases; Gastroenterology; Electronic journals; Periodicals; Case studies; Periodicals; 616.33
• DOI: 10.1155/2016/7092434
• Languages: English
• ISSNs: 2090-6528

Abstract

Abstract : Drug-induced liver injury (DILI) with features of autoimmunity (AI) is a challenging diagnosis to make particularly due to its apparent corticosteroid responsiveness. We present the case of a 74-year-old woman who presented with a 2-week history of jaundice and fatigue. She was initially diagnosed with autoimmune hepatitis (AIH) based on biochemical and histological characteristics and prompt response with budesonide but a biochemical relapse occurred soon after inadvertent rechallenge with irbesartan, a drug that she had discontinued prior to her presentation but was not initially considered to be a cause of her symptoms.