Investigation of Serum Oxidized Low-Density Lipoprotein IgG Levels in Patients with Angiographically Defined Coronary Artery Disease. (3rd February 2014)

• Record Type: Journal Article
• Authors: Moohebati, Mohsen; Kabirirad, Vahid; Ghayour-Mobarhan, Majid; Esmaily, Habibollah; Tavallaie, Shima; Akhavan Rezayat, Amir; Pourghadamyari, Hossein; Sahebkar, Amirhossein
• Other Names: Peter Karlheinz Academic Editor.
• Is Part Of: International journal of vascular medicine. Volume 2014(2014)
• Publication Date: 2014-02-03
• Subjects: Blood-vessels -- Diseases -- Periodicals; 616.13005
• DOI: 10.1155/2014/845960
• Languages: English
• ISSNs: 2090-2824

Abstract

Abstract : It has been suggested that antioxidized low-density lipoprotein (anti-oxLDL) antibodies play a role in the pathogenesis of atherosclerosis. The aim of this study was to measure serum ox-LDL IgG levels in 31 patients with angiographically defined coronary artery disease (CAD) (≥50% stenosis in at least one major coronary artery; CAD + group) and compare these levels with those of 32 subjects with <50% coronary stenosis (CAD − group) and 24 healthy age- and sex-matched controls using ELISA. We did not find any significant difference between CAD +, CAD −, and control groups in regard to oxLDL IgG levels (P = 0.83 ). Serum oxLDL IgG levels did not differ between 1VD (one vessel disease), 2VD (2 vessels disease), and 3VD (3 vessels disease) subgroups of CAD + patients (P = 0.20 ). Serum anti-oxLDL titers were only significantly correlated with LDL-C in the CAD + group (P < 0.05 ) and waist and hip circumference (P < 0.05 andP < 0.01, resp.) in the CAD − group. In stepwise regression analysis, none of the conventional cardiovascular risk factors was associated with serum ox-LDL IgG levels. The present results suggest that serum levels of ox-LDL IgG are neither associated with the presence and severity of CAD nor with the conventional cardiovascular risk factors.