Leukocyte Counts, Myeloperoxidase, and Pregnancy-Associated Plasma Protein A as Biomarkers for Cardiovascular Disease: Towards a Multi-BiomarkerApproach. (3rd May 2010)

• Record Type: Journal Article
• Authors: Lobbes, M. B. I.; Kooi, M. E.; Lutgens, E.; Ruiters, A. W.; Lima Passos, V.; Braat, S. H. J. G.; Rousch, M.; Ten Cate, H.; van Engelshoven, J. M. A.; Daemen, M. J. A. P.; Heeneman, S.
• Other Names: Arko Frank R. Academic Editor.
• Is Part Of: International journal of vascular medicine. Volume 2010(2010)
• Publication Date: 2010-05-03
• Subjects: Blood-vessels -- Diseases -- Periodicals; 616.13005
• DOI: 10.1155/2010/726207
• Languages: English
• ISSNs: 2090-2824

Abstract

Abstract : We evaluated leukocyte counts and levels of CRP, fibrinogen, MPO, and PAPP-A in patients with stable and unstable angina pectoris, acute myocardial infarction, and healthy controls. All biomarkers were analyzed again after 6 months. Leukocyte counts and concentrations of fibrinogen, CRP, MPO, and PAPP-A were significantly increased in patients with acute myocardial infarction. Leukocyte counts and concentrations of MPO were significantly increased in patients with unstable angina pectoris compared with controls. After 6 months, leukocyte counts and MPO concentrations were still increased in patients with acute myocardial infarction when compared to controls. Discriminant analysis showed that leukocyte counts, MPO, and PAPP-A concentrations classified study group designation for acute coronary events correctly in 83% of the cases. In conclusion, combined assessment of leukocyte counts, MPO, and PAPP-A was able to correctly classify acute coronary events, suggesting that this could be a promising panel for a multibiomarker approach to assess cardiovascular risk.