The Use of Dried Blood Spots for the Quantification of Antihypertensive Drugs. (1st August 2018)

• Record Type: Journal Article
• Authors: Chernonosov, Alexander
• Other Names: Jönsson Jan Åke Academic Editor.
• Is Part Of: International journal of analytical chemistry. Volume 2018(2018)
• Publication Date: 2018-08-01
• Subjects: Chemistry, Analytic -- Periodicals; 543.05
• DOI: 10.1155/2018/3235072
• Languages: English
• ISSNs: 1687-8760

Abstract

Abstract : Hypertension or high blood pressure is a harbinger of cardiovascular diseases. There are several classes of drugs used to treat hypertension. This review discusses the use of dried blood spots (DBSs) for the quantification by mass spectrometry (MS), tandem mass spectrometry (MS/MS), or, in some cases, by fluorescence detection methods the following antihypertensive medications: angiotensin-converting enzyme inhibitors (ramipril, ramiprilat, captopril, and lisinopril); angiotensin II receptor antagonists (valsartan, irbesartan, losartan, and losartan carboxylic acid); calcium channel blockers (verapamil, amlodipine, nifedipine, pregabalin, and diltiazem); α blockers (guanfacine, doxazosin, and prazosin); β blockers (propranolol, bisoprolol, atenolol, and metoprolol); endothelin receptor antagonists (bosentan and ambrisentan); and statins (simvastatin, atorvastatin, and rosuvastatin).