Suspected Lonely Mouse Syndrome as a Cage Effect in a Drug Safety Study. (9th May 2018)

• Record Type: Journal Article
• Authors: Ye, Xiaobu; Itzoe, MariaLisa; Sarabia-Estrada, Rachel; DeTolla, Louis; Tyler, Betty M.; Guarnieri, Michael
• Other Names: Ortega-Pacheco Antonio Academic Editor.
• Is Part Of: Journal of veterinary medicine. Volume 2018(2018)
• Publication Date: 2018-05-09
• Subjects: Veterinary medicine -- Periodicals; 636.08905
• DOI: 10.1155/2018/9562803
• Languages: English
• ISSNs: 2356-7708

Abstract

Abstract : Studies have demonstrated that buprenorphine, a front line drug for veterinary analgesia, may alleviate symptoms of chronic pain. A cage side observation protocol was used to record behavioral signs in a mouse clinical trial of extended release buprenorphine. A retrospective review of the observations for signs of pain and stress revealed that mice given a fivefold overdose of buprenorphine (16.25 mg/kg) showed lethargy and facial signs associated with stress. However, similar signs were observed in the drug-free control mice as early as Day 3 of single-cage housing. This appears to be the first report of cage effects in a clinical trial for a veterinary drug.