A sequential one-pot strategy for the synthesis of triterpenoid saponins in ionic liquid [emim][OTf]. Issue 1 (January 2019)

• Record Type: Journal Article
• Authors: Song, Yiming; Guo, Tiantian; Liu, Qingchao; Song, Weiguo; Li, Fahui
• Is Part Of: Journal of chemical research. Volume 43:Issue 1/2(2019)
• Page Start: 20
• Page End: 25
• Publication Date: 2019-01
• Subjects: [emim][OTf] -- Mbp thioglycoside -- N-phenyltrifluoroacetimidates -- one-pot sequential glycosylation -- trichloroacetimidates; Chemistry -- Research -- Periodicals; Chemistry -- Periodicals; 540.5
• DOI: 10.1177/1747519819831866
• Languages: English
• ISSNs: 1747-5198

Abstract

1-Ethyl-3-methylimidazolium trifluoromethanesulfonate ([emim][OTf]) is an efficient co-solvent and co-promoter for one-pot sequential glycosylation with the combined use of thioglycosides and trichloroacetimidates (or N -phenyltrifluoroacetimidates) donors at room temperature. One-pot glycosylation is efficient for the synthesis of triterpenoid saponins with the combined use of N -phenyltrifluoroacetimidate donors and 2-methyl-5-tert-butylphenyl (Mbp) thioglycoside donors in [emim][OTf].