Multiple Autoimmune Propensity and B-Non-Hodgkin Lymphoma: Cause or Effect?. (13th April 2011)

• Record Type: Journal Article
• Authors: Koumati, E.; Palassopoulou, M.; Matsouka, P.; Polyzos, A.; Dalekos, G. N.; Zachou, K.
• Other Names: Betterle Corrado Academic Editor.
• Is Part Of: Autoimmune diseases. Volume 2011(2011)
• Publication Date: 2011-04-13
• Subjects: Autoimmune diseases -- Periodicals; 571.97305
• DOI: 10.4061/2011/841325
• Languages: English
• ISSNs: 2090-0422

Abstract

Abstract : We report a case of multiple autoimmunity consisting of the presence of autoimmune haemolytic anaemia (AIHA), antimitochondrial antibodies (AMAs), and antiphospholipid antibodies (APLAbs) as the presenting manifestations of an extrahepatic B-non-Hodgkin lymphoma (B-NHL) in a 63-year-old woman. The patient presented with fatigue attributed to severe AIHA. Due to increased serum IgM andγ -GT levels, an investigation for AMA was performed, which proved positive with anti-M2 specificity. A prolongation of activated partial thromboplastin time (aPTT) led to the determination of APLAbs (lupus anticoagulant and other APLAbs) which were also positive. Bone marrow biopsy in combination with immmunohistochemical studies established the diagnosis of lymphoplasmacytic B-NHL. Ten months later, B-NHL was in remission while AMA and APLAbs were still positive. In conclusion, we documented the coexistence of multiple autoimmune reactions together with B-NHL highlighting the possible common pathogenetic pathways of the two entities.