Efficacy of Female Rat Models in Translational Cardiovascular Aging Research. (31st December 2014)

• Record Type: Journal Article
• Authors: Rice, K. M.; Fannin, J. C.; Gillette, C.; Blough, E. R.
• Other Names: Ferraro F. R. Academic Editor.
• Is Part Of: Journal of aging research. Volume 2014(2014)
• Publication Date: 2014-12-31
• Subjects: Aging -- Periodicals; Aging -- Research -- Periodicals; 612.6705
• DOI: 10.1155/2014/153127
• Languages: English
• ISSNs: 2090-2204

Abstract

Abstract : Cardiovascular disease is the leading cause of death in women in the United States. Aging is a primary risk factor for the development of cardiovascular disease as well as cardiovascular-related morbidity and mortality. Aging is a universal process that all humans undergo; however, research in aging is limited by cost and time constraints. Therefore, most research in aging has been done in primates and rodents; however it is unknown how well the effects of aging in rat models translate into humans. To compound the complication of aging gender has also been indicated as a risk factor for various cardiovascular diseases. This review addresses the systemic pathophysiology of the cardiovascular system associated with aging and gender for aging research with regard to the applicability of rat derived data for translational application to human aging.