Metabolic Phenotype and Adipose Tissue Inflammation in Patients with Chronic Obstructive Pulmonary Disease. (2nd December 2010) - Skyba, Peter
Abstract : Potential links between metabolic derangements and adipose tissue (AT) inflammation in patients with chronic obstructive pulmonary disease (COPD) are unexplored. We investigated AT expressions of interleukin (IL)-6, tumor necrosis factor (TNF)- α, CD68 (macrophage cell surface receptor), caspase-3, and Bax, and their relationships to the metabolic phenotype in nine cachectic, 12 normal-weight, 12 overweight, and 11 obese patients with COPD (age62.3 ± 7.2 years). With increasing body mass index, increases in AT expressions of IL-6, TNF- α, and CD68 were observed (P < .001 ;P = .005 ;P < .001, resp.), in association with reduced insulin sensitivity (P < .001 ). No differences were observed between cachectic and normal-weight patients in AT expressions of inflammatory or proapoptotic markers. Adipose tissue CD68 and TNF- α expressions predicted insulin sensitivity independently of known confounders (P = .005 ;P = .025 ;R 2 = 0.840 ). Our results suggest that AT inflammation in obese COPD patients relates to insulin resistance. Cachectic patients remain insulin sensitive, with no AT upregulation of inflammatory or proapoptotic markers.