Unraveling the Mechanobiology of the Immune System. Issue 4 (7th January 2019)

• Record Type: Journal Article
• Authors: Kim, Jeong‐Ki; Shin, Yu Jung; Ha, Leslie Jaesun; Kim, Deok‐Ho; Kim, Dong‐Hwee
• Is Part Of: Advanced healthcare materials. Volume 8:Issue 4(2019)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2019-01-07
• Subjects: immune cells -- immune response -- mechanobiology -- mechanoregulation; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/adhm.201801332
• Languages: English
• ISSNs: 2192-2640

Abstract

Abstract: Cells respond and actively adapt to environmental cues in the form of mechanical stimuli. This extends to immune cells and their critical role in the maintenance of tissue homeostasis. Multiple recent studies have begun illuminating underlying mechanisms of mechanosensation in modulating immune cell phenotypes. Since the extracellular microenvironment is critical to modify cellular physiology that ultimately determines the functionality of the cell, understanding the interactions between immune cells and their microenvironment is necessary. This review focuses on mechanoregulation of immune responses mediated by macrophages, dendritic cells, and T cells, in the context of modern mechanobiology. Abstract : Physical factors in the immune system govern tissue homeostasis. This review articulates mechanoregulation of immune responses based on extensive research findings in the context of modern mechanobiology. Physical insights into the stimulus‐responsive changes of phenotype and functionality of immune cells provide a noble perspective on the homeostatic immunity and self‐defending system.