Acute promyelocytic leukemia presenting as recurrent spinal myeloid sarcomas 3 years before developing leukemia: A case report with review of literature. Issue 2 (8th January 2019)

• Record Type: Journal Article
• Authors: Yamashita, Tomoko; Nishijima, Akihiko; Noguchi, Yuma; Narukawa, Kensuke; Oshikawa, Gaku; Takano, Hina
• Is Part Of: Clinical case reports. Volume 7:Issue 2(2019)
• Page Start: 316
• Page End: 321
• Publication Date: 2019-01-08
• Subjects: acute promyelocytic leukemia -- fluorescence in situ hybridization -- myeloid sarcoma -- spinal tumor; Medicine -- Periodicals; 616.09
• DOI: 10.1002/ccr3.1991
• Languages: English
• ISSNs: 2050-0904

Abstract

Key Clinical Message: The de novo myeloid sarcoma (MS) type of acute promyelocytic leukemia (APL) is rare, and clinical features may differ from extramedullary diseases in advanced APL. Many cases occur as a spinal tumor, and some occur in the absence of bone‐marrow diseases or coagulation abnormalities. Fluorescence in situ hybridization analysis of MS tissue is useful for accurate diagnosis, even in preserved tissue. Abstract : The de novo myeloid sarcoma (MS) type of acute promyelocytic leukemia (APL) is rare, and clinical features may differ from extramedullary diseases in advanced APL. Many cases occur as a spinal tumor, and some occur in the absence of bone‐marrow diseases or coagulation abnormalities. Fluorescence in situ hybridization analysis of MS tissue is useful for accurate diagnosis, even in preserved tissue.