Sesquiterpenes and lignans from the flower buds of Daphne genkwa and their nitric oxide inhibitory activities. Issue 24 (17th December 2018)

• Record Type: Journal Article
• Authors: Zhang, Chun-Yang; Luo, Lan; Xia, Jing; Song, Ya-Nan; Zhang, Li-Jun; Zhang, Miao; Rahman, Khalid; Ye, Yin; Zhang, Hong; Zhu, Jian-Yong
• Is Part Of: Natural product research. Volume 32:Issue 24(2018)
• Page Start: 2893
• Page End: 2899
• Publication Date: 2018-12-17
• Subjects: Daphne genkwa -- sesquiterpene -- lignan -- nitric oxide; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2017.1389937
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Chemical investigation of the Daphne genkwa has led to the isolation of four sesquiterpenes (1a /1b, 2 and3 ), including one pair of sesquiterpene enantiomers (1a /1b ), 1a is a new compound (+)- 4 - hydroxy - 10 - epirotundone, and twelve lignans (4 –15 ). Their structures were elucidated by spectroscopic analysis, and the absolute configurations of1a /1b were determined by CD analysis. All compounds were examined for their inhibitory effects on the nitric oxide (NO) production induced by lipopolysaccharide (LPS) in BV-2 microglial cells, and compounds7 –10 exhibited pronounced inhibition on NO production with IC50 values in the range of 5.8–10.2 μ M, being more active than the positive control, quercetin (IC50 = 17.0 μ M). Abstract :