Association of Activity Altering Genotypes - Tyr113His and His139Arg in Microsomal Epoxide Hydrolase Enzyme with Esophageal Squamous Cell Carcinoma. (4th July 2019)

• Record Type: Journal Article
• Authors: Nabi, Sumaiya; Bhat, Gulzar Ahmad; Iqbal, Beenish; Lone, Mohd Maqbool; Lone, Ghulam Nabi; Khan, Maroof Ahmad; Dar, Nazir Ahmad
• Is Part Of: Nutrition and cancer. Volume 71:Number 5(2019)
• Page Start: 806
• Page End: 817
• Publication Date: 2019-07-04
• Subjects: Cancer -- Periodicals; Nutrition -- Periodicals; Cancer; Nutrition; Periodicals; 616.9940654
• DOI: 10.1080/01635581.2018.1484934
• Languages: English
• ISSNs: 0163-5581

Abstract

Abstract: The study aimed to explore the relationship of microsomal epoxide hydrolase (mEH) exon 3 (Tyr113His) and exon 4 (His139Arg) polymorphisms and predicted mEH activity with esophageal squamous cell carcinoma (ESCC) risk. 482 histologically confirmed cases and equal number of matched controls were analyzed by polymerase chain reaction-restriction length polymorphism (PCR-RFLP). Conditional logistic regression models were used to examine the association of polymorphisms with ESCC. We noted exon 3 slow genotype (OR = 6.57; CI 3.43–12.57) as well as predicted low mEH activity (OR = 3.99; CI 2.32–6.85) was associated with the ESCC risk. Elevated ESCC risk estimates were seen in smokers independent of genotypes but the association was stronger among smokers with exon 3 variant (OR = 6.67; 3.29–13.53) and low activity (OR = 7.52; CI 3.46–16.37) genotypes. Positive family history of cancer synergistically increased ESCC risk in the individuals who harbored exon 3 (OR = 13.59; CI 5.63–32.81) or altered mEH activity genotypes (OR = 13.35; CI 5.10–34.94). Significant interaction was seen between mEH exon 3 and exon 4 genotypes ( P = 0.006) and between predicted mEH activity and positive family history of cancer ( P = 0.018). These findings suggest association of ESCC risk with mEH polymorphisms which get modified by tobacco smoking and positive family history of cancer.