Development and optimization of self-nanoemulsifying drug delivery systems (SNEDDS) for curcumin transdermal delivery: an anti-inflammatory exposure. (3rd July 2019)

• Record Type: Journal Article
• Authors: Altamimi, Mohammad A.; Kazi, Mohsin; Hadi Albgomi, Mshaan; Ahad, Abdul; Raish, Mohammad
• Is Part Of: Drug development and industrial pharmacy. Volume 45:Number 7(2019)
• Page Start: 1073
• Page End: 1078
• Publication Date: 2019-07-03
• Subjects: Curcumin -- thymoquinone -- self-nanoemulsifying lipid based formulation -- transdermal drug delivery; Pharmaceutical chemistry -- Periodicals; Pharmaceutical industry -- Periodicals; Drug Industry -- Periodicals; Technology, Pharmaceutical -- Periodicals; 615.05
• DOI: 10.1080/03639045.2019.1593440
• Languages: English
• ISSNs: 0363-9045

Abstract

Abstract: The purpose of this work is to develop novel lipid-based self-nanoemulsifying drug delivery systems (SNEDDS) as carriers for transdermal delivery of curcumin. SNEDDS containing black seed oil, medium chain mono- and diglycerides and surfactants, were prepared as curcumin delivery vehicles. Their formation spontaneity, morphology, droplet size, and drug loading were evaluated. Gel preparation containing two of the SNEDDS formulations were used in the carrageenan induced paw edema to evaluate the anti-inflammatory effect. Results showed droplet size as low as 71 nm. The highest drug loading was observed with SNEDDS-F6 of ∼45 mg/g. In in-vivo investigation, SNEDDS-F6 exhibited significant anti-inflammatory activities in terms of 80% reduction in paw edema when compared with positive control. The prepared SNEDDS with the elevated entrapment efficiency, good transdermal penetration ability could be a suitable candidate for effective transdermal curcumin skin delivery.