MALAT1 long non-coding RNA and breast cancer. Issue 6 (3rd June 2019)

• Record Type: Journal Article
• Authors: Arun, Gayatri; Spector, David L.
• Is Part Of: RNA biology. Volume 16:Issue 6(2019)
• Page Start: 860
• Page End: 863
• Publication Date: 2019-06-03
• Subjects: LncRNA -- metastasis -- MALAT1 -- breast cancer; RNA -- Periodicals; Molecular biology -- Periodicals; Molecular biology; RNA; Periodicals; 572.8805
• DOI: 10.1080/15476286.2019.1592072
• Languages: English
• ISSNs: 1547-6286

Abstract

ABSTRACT: Non-coding RNAs are becoming major players in disease pathogenesis such as cancer. Metastasis Associated Lung Adenocarcinoma Transcript 1 (MALAT1) is a nuclear enriched long non-coding RNA that is generally overexpressed in patient tumors and metastases. Overexpression of MALAT1 has been shown to be positively correlated with tumor progression and metastasis in a large number of tumor types including breast tumors. Surprisingly, a recent report by Kim et al shows a metastasis suppressive role for Malat1 . Here, we discuss these results in the context of a large body of published literature that support a pro-tumorigenic role for MALAT1 in order to gain potential insights into the basis of these observed differences.