Metal-nucleobase hybrid nanoparticles for enhancing the activity and stability of metal-activated enzymes. Issue 44 (14th May 2019)

• Record Type: Journal Article
• Authors: He, Jie; Sun, Shanshan; Lu, Mingzhu; Yuan, Qipeng; Liu, Yanhui; Liang, Hao
• Is Part Of: Chemical communications. Volume 55:Issue 44(2019)
• Page Start: 6293
• Page End: 6296
• Publication Date: 2019-05-14
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c9cc03155c
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A novel strategy for enhancing the activity and stability of metal-activated enzyme methionine adenosyltransferase (MAT) by allosteric control and confinement of metal-nulceobase hybrid coordination. Abstract : A novel strategy for enhancing the activity and stability of metal-activated enzymes by allosteric control and confinement of metal-nulceobase hybrid coordination was reported in this study. Despite the lack of active Mg 2+ ions, methionine adenosyltransferase (MAT) immobilized by Zn2 (adenine) still exhibited robust catalytic activity and stability at pH 3 and 80 °C.