Gram-scale fabrication of Bi@C nanoparticles through one-step hydrothermal method for dual-model imaging-guided NIR-II photothermal therapy. Issue 20 (15th May 2019)

• Record Type: Journal Article
• Authors: Zhen, Wenyao; An, Shangjie; Wang, Wei; Liu, Yang; Jia, Xiaodan; Wang, Chao; Zhang, Mengchao; Jiang, Xiue
• Is Part Of: Nanoscale. Volume 11:Issue 20(2019)
• Page Start: 9906
• Page End: 9911
• Publication Date: 2019-05-15
• Subjects: Nanoscience -- Periodicals; Nanotechnology -- Periodicals; 620.505
• DOI: 10.1039/c9nr01557d
• Languages: English
• ISSNs: 2040-3364

Abstract

Abstract : Bi@C nanoparticles were fabricated at the gram scale through a one-step hydrothermal method for dual-model imaging-guided NIR-II photothermal therapy. Abstract : At present, increasing attention is being paid to photothermal therapy corresponding to the second near infrared (NIR-II) range (1000–1700 nanometers); however, its biomedical applications related to carbon-based nanomaterials (CNMs) have always been limited by the large-scale fabrication of excellent diagnostic probes with a suitable size and optical absorption cross-section. Herein, we successfully prepared Bi@C nanoparticles with a suitable size and high output (3.14 g per patch) through a one-pot hydrothermal method. By combining Bi with carbon, the optical absorption in the NIR-II range was enhanced compared to that for single carbon; moreover, Bi@C could no longer be easily oxidized due to the protection of outer C compared with individual Bi. Furthermore, because of the high atomic number of Bi ( Z = 83), the Bi@C nanoparticles exhibited computed imaging contrast properties. According to the in vitro and in vivo experiments, the Bi@C nanoparticles could ablate cancer cells under illumination with a 1064 nm laser with deeper penetration and an appropriate permissible exposure (MPE) to the laser (1 W cm −2 ), showing excellent performance for the diagnosis and treatment of tumors. This study provides a simple method to synthesize metal–carbon nanocomposites to enhance the NIR-II optical absorption efficiency for effective deep-seated tumor photothermal therapy and will further broaden the applications of CNMs.