Circulating cytokine profile in anti-neutrophilic cytoplasmatic autoantibody-associated vasculitis: prediction of outcome?. Issue 4 (2004)

• Record Type: Journal Article
• Authors: Ohlsson Ohlsson, Sophie Sophie; Wieslander Wieslander, Jörgen Jörgen; Segelmark Segelmark, Mårten Mårten
• Is Part Of: Mediators of inflammation. Volume 13:Issue 4(2004)
• Page Start: 275
• Page End: 283
• Publication Date: 2004
• Subjects: Vasculitis -- Interleukin-6 -- Interleukin-8 -- Interleukin-10 -- Anti-neutrophilic cytoplasmatic autoantibodies -- Inflammation -- Autoimmunity; Inflammation -- Mediators -- Periodicals; Biological response modifiers -- Periodicals; Inflammation (Pathologie) -- Médiateurs; Immunomodulateurs; Biological response modifiers; Inflammation -- Mediators; Immunology; Autacoids; Immunologic Factors; Cell Adhesion Molecules; Cell Communication; Cytokines; Inflammation; Periodicals; Electronic journals; 616.0473
• DOI: 10.1080/09629350400003100
• Languages: English
• ISSNs: 0962-9351

Abstract

Abstract : AIMS : The anti-neutrophilic cytoplasmatic autoantibody-associated vasculitides (AASV) are diseases of relapsing-remitting inflammation. Here we explore the cytokine profile in different phases of disease, looking for pathogenic clues of possible prognostic value. Results : Interleukin (IL)-6, IL-8 and IL-10 were significantly elevated in plasma. Patients in the stable phase who subsequently developed adverse events had higher IL-8 values. Patients in the stable phase who relapsed within 3 months had lower IL-10 values and higher IL-6 levels. Conclusions : Patients with AASV have raised circulating cytokine levels compared with healthy controls, even during remission. Raised IL-8 seems associated with poor prognosis. Lower levels of IL-10 and higher levels of IL-6 herald a greater risk of relapse. Patients with systemic vasculitis in clinical remission have persistent disease activity, kept under control by inhibitory cytokines.