Cobalt(II)–catalyzed C8H alkoxylation of 1-naphthylamine derivatives with alcohols. Issue 11 (15th March 2019)

• Record Type: Journal Article
• Authors: Zhang, Tingfang; Zhu, Hongmei; Yang, Fan; Wu, Yusheng; Wu, Yangjie
• Is Part Of: Tetrahedron. Volume 75:Issue 11(2019)
• Page Start: 1541
• Page End: 1547
• Publication Date: 2019-03-15
• Subjects: Cobalt catalysis -- Alkoxylation -- Remote CH activation -- 1-Naphthylamine; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tet.2019.02.002
• Languages: English
• ISSNs: 0040-4020

Abstract

Abstract: An efficient protocol for cobalt (II)-catalyzed regioselective aryl C8H bond alkoxylation of 1-naphthylamine derivatives with readily available alcohols has been developed, demonstrating an efficient approach to 8-alkoxy-1-naphthylamine derivatives with good functional group tolerance. Note that the picolinamide moiety as a bidentate directing group may play a key role in this regioselective transformation. Graphical abstract: An efficient protocol for cobalt (II)-catalyzed regioselective aryl C8H bond alkoxylation of 1-naphthylamine derivatives with readily available alcohols has been developed, demonstrating an efficient approach to 8-alkoxy-1-naphthylamine derivatives with good functional group tolerance. Note that the picolinamide moiety as a bidentate directing group may play a key role in this regioselective transformation.Image 1