Neutrophils: Homing in on the myeloid mechanisms of metastasis. (June 2019)

• Record Type: Journal Article
• Authors: Leach, Joshua; Morton, Jennifer P.; Sansom, Owen J.
• Is Part Of: Molecular immunology. Volume 110(2019:Jun.)
• Page Start: 69
• Page End: 76
• Publication Date: 2019-06
• Subjects: APC antigen presenting cell -- CCL C-C motif chemokine ligand -- CCR C-C motif chemokine receptor -- CXCL C-X-C motif chemokine ligand -- CXCR C-X-C motif chemokine receptor -- ECM extracellular matrix -- EMT epithelial to mesenchymal transition -- FACS fluorescence-activated cell sorting -- FGF fibroblast growth factor -- G-CSF granulocyte-colony stimulating factor -- GM-CSF granulocyte-macrophage colony stimulating factor -- gMDSCs granulocytic myeloid-derived suppressor cells -- HOCL hypochlorous acid -- ICAM intercellular adhesion molecule -- IL interleukin -- IFN interferon -- iNOS Inducible nitric oxide synthase -- MAPK mitogen-activated protein kinase -- MET mesenchymal-to-epithelial transition -- MMP matrix metalloproteinase -- NET neutrophil extracellular trap -- NF-κB nuclear factor kappa B subunit 1 -- NK Natural Killer -- NLR neutrophil to lymphocyte ratio -- PD1 programmed cell death protein 1 -- PI3K phosphoinositide 3-kinase -- ROS reactive oxygen species -- SDF1 stromal cell-derived factor 1 -- STAT3 signal transducer and activator of transcription 3 -- TGFβ transforming growth factor beta -- TAM tumour-associated macrophages -- TAN tumour-associated neutrophils -- TIMP-1 tissue inhibitor of metalloprotease 1 -- TLR toll-like receptor -- TNF tumour necrosis factor -- VEGF vascular endothelial growth factor; Epithelial cancer -- Metastasis -- Neutrophils -- Myeloid cells -- Tumour microenvironment; Immunochemistry -- Periodicals; Molecular biology -- Periodicals; Immunochemistry -- Periodicals; Allergy and Immunology -- Periodicals; Molecular Biology -- Periodicals; Immunochimie -- Périodiques; Biologie moléculaire -- Périodiques; Immunochemistry; Molecular biology; Periodicals; Electronic journals; 571.96
• DOI: 10.1016/j.molimm.2017.12.013
• Languages: English
• ISSNs: 0161-5890

Abstract

Highlights: Neutrophils play important roles throughout the metastatic process. Tumour progression and invasion are influenced by infiltrating neutrophils. Signalling from neutrophils can enhance survival of circulating tumour cells. Neutrophils play a key role in establishing the metastatic niche. Abstract: The metastasis cascade is complex and comprises several stages including local invasion into surrounding tissue, intravasation and survival of tumour cells in the circulation, and extravasation and colonisation of a distant site. It is increasingly clear that these processes are driven not only by signals within the tumour cells, but are also profoundly influenced by stromal cells and signals in the tumour microenvironment. Amongst the many cell types within the tumour microenvironment, immune cells such as lymphocytes, macrophages and neutrophils play a prominent role in tumour development and progression. Neutrophils, however, have only recently emerged as important players, particularly in metastasis. Here we review the current evidence suggesting a multi-faceted role for neutrophils in the metastatic cascade.