Detailed analysis of health-related quality of life after out-of-hospital cardiac arrest. (February 2019)

• Record Type: Journal Article
• Authors: Bohm, Mattias; Lilja, Gisela; Finnbogadóttir, Hafrún; Cronberg, Tobias; Undén, Johan; Friberg, Hans; Kjærgaard, Jesper; Nielsen, Niklas; Wise, Matt P.; Åkerman, Eva
• Is Part Of: Resuscitation. Volume 135(2019)
• Page Start: 197
• Page End: 204
• Publication Date: 2019-02
• Subjects: Cardiac arrest -- Quality of life -- SF-36v2 -- Outcome -- Cross-sectional studies; Resuscitation -- Periodicals; Resuscitation -- Periodicals; Réanimation -- Périodiques; Electronic journals; 616.025
• DOI: 10.1016/j.resuscitation.2018.10.028
• Languages: English
• ISSNs: 0300-9572

Abstract

Abstract: Aim: To describe the detailed health-related quality of life (HRQoL) in survivors from the TTM-trial and to investigate potential differences related to sex and age. Methods: This is a cross-sectional study originating from a large prospective international, multicentre trial, including 442 respondents who answered the Short Form-36 item Questionnaire Health Survey version 2 ® (SF-36v2 ® ) at a structured follow-up 6 months after out-of-hospital cardiac arrest (OHCA). Statistical analysis between independent groups were performed with Mann-Whitney U or Chi-square. Age was analysed primarily as a dichotomised variable. Results: Although overall physical and mental health were within the normal range, a substantial proportion of respondents had impaired function at domain-specific levels, particularly in Role-Physical (50%) and Role-Emotional (35%). Females scored significantly lower than males in; Physical Functioning (41.7 vs. 47.9, p < 0.001), Role-Physical (40.4 vs. 44.3, p = 0.02), General Health (47.0 vs. 50.5, p = 0.02), Vitality (47.2 vs. 52.7, p < 0.001), and Role-Emotional (41.5 vs. 46.2, p = 0.009). Those ≤65 years scored significantly better in Physical Functioning (47.9 vs. 44.1 p < 0.001), while those >65 years scored significantly better in Vitality (50.8 vs. 53.7, p = 0.006) and Mental Health (50.3 vs. 52.6, p = 0.04). Conclusions: Many OHCA survivors demonstrated impaired function in HRQoL at a domain level, despite most patients reporting an acceptable general HRQoL. Females reported worse HRQoL than males. Older age was associated with a worse Physical Functioning but better Vitality and Mental Health. Role-Physical and Role-Emotional aspects of health were especially affected, even when effects of age and sex where accounted for.