The Diagnostic and Differential Diagnosis Utility of Cerebrospinal Fluid α-Synuclein Levels in Parkinson's Disease: A Meta-Analysis. (29th July 2015)

• Record Type: Journal Article
• Authors: Zhou, Bo; Wen, Min; Yu, Wen-Feng; Zhang, Chun-Lin; Jiao, Ling
• Other Names: Colosimo Carlo Academic Editor.
• Is Part Of: Parkinson's disease. Volume 2015(2015)
• Publication Date: 2015-07-29
• Subjects: Parkinson's disease -- Periodicals; Parkinson's disease -- Treatment -- Periodicals; 616.833005
• DOI: 10.1155/2015/567386
• Languages: English
• ISSNs: 2090-8083

Abstract

Abstract : Several recent studies showed that α -syn might be a potential diagnostic biomarker for PD in human cerebrospinal fluid (CSF), but the results were inconsistent. The purpose of this meta-analysis was to investigate the diagnostic and differential diagnosis efficacy of CSF α -syn in PD. Studies which measured CSF α -syn or α -syn oligomers in patients with PD and met the inclusion criteria were included in the analysis. Results of the meta-analysis indicated that mean concentration of CSF α -syn was significantly lower in PD compared to controls and significantly higher in PD compared to multiple system atrophy (MSA). No significant difference in mean concentration of CSF α -syn was found between PD and dementia with Lewy bodies (DLB). Mean concentration of CSF α -syn was slightly decreased in PD compared to progressive supranuclear palsy (PSP). Mean concentration of CSF α -syn oligomers was significantly higher in PD than control. These results support the findings that CSF α -syn may be a potential diagnostic and differential diagnosis biomarker in PD compared to control and MSA but not DLB. Furthermore, α -syn oligomer may represent a better biomarker for diagnosis of PD.