Relationship between interleukin-17A and isolated coronary ectasia. (March 2019)

• Record Type: Journal Article
• Authors: Uygun, Turgut; Demir, Bülent; Tosun, Veysel; Ungan, İsmail; Kural, Alev; Çiftçi, Rumeysa; Fatullayev, Fuad
• Is Part Of: Cytokine. Volume 115(2019)
• Page Start: 84
• Page End: 88
• Publication Date: 2019-03
• Subjects: Atherosclerosis -- Coronary artery ectasia -- Interleukin-17A -- Red cell distribution width -- Fibrinogen; Cytokines -- Periodicals; 571.844
• DOI: 10.1016/j.cyto.2018.11.015
• Languages: English
• ISSNs: 1043-4666

Abstract

Highlights: Coronary artery ectasia may be an inflammatory process. Interleukin-17A, fibrinogen, and red cell distribution width are higher in coronary artery ectasia patients. Interleukin-17A is associated with coronary artery ectasia. Abstract: The aim of this study was to evaluate serum interleukin (IL)-17A levels in patients with coronary artery ectasia (CAE), the relationship between IL and 17A and CAE, and to determine the relationship between the severity of coronary ectasia and the level of IL-17A. In total, 41 patients (19 female and 22 male) with ischemic symptoms whose non-invasive cardiac tests were positive for myocardial ischemia, and in whom coronary artery ectasia were detected after coronary angiography, and 45 patients (32 female and 13 male) with normal coronary arteries were included in this study. Echocardiographic assessments were performed. Serum IL-17A levels of all patients were evaluated using an enzyme-linked immunosorbent assay. IL-17A levels of the group with isolated coronary artery ectasia were significantly higher compared with the control group (4.86 ± 3.24 and 1.37 ± 1.56 ng/ml, respectively; p < 0.001). There was no correlation between the levels of IL-17A and the extension of the CAE, but IL-17A levels were high in both groups. CAE patients have significantly increased levels of IL-17A, fibrinogen, and RDW compared to patients with normal coronary arteries. It was demonstrated that increased levels of IL-17A were associated with ectasia formation in CAE patients.