Contemporary medicinal-chemistry strategies for the discovery of selective butyrylcholinesterase inhibitors. Issue 2 (February 2019)

• Record Type: Journal Article
• Authors: Jing, Lanlan; Wu, Gaochan; Kang, Dongwei; Zhou, Zhongxia; Song, Yuning; Liu, Xinyong; Zhan, Peng
• Is Part Of: Drug discovery today. Volume 24:Issue 2(2019)
• Page Start: 629
• Page End: 635
• Publication Date: 2019-02
• Subjects: Drugs -- Design -- Periodicals; Drugs -- Research -- Periodicals; 615.1
• DOI: 10.1016/j.drudis.2018.11.012
• Languages: English
• ISSNs: 1359-6446

Abstract

Graphical abstract: Highlights: BChE is considered a promising drug target for the treatment of moderate to severe Alzheimer's disease. The development of selective BChE inhibitors will move on from trial-and-error approaches to increasingly sophisticated strategies. The insightful application of critical molecular design elements is a very effective strategy to improve the success rates of target-based drug discovery. New medicinal chemistry concepts and techniques can be utilized for the discovery of novel and selective BChE inhibitors. Abstract : Butyrylcholinesterase (BChE) is considered a promising drug target for the treatment of moderate to severe Alzheimer's disease (AD). Here, we review medicinal-chemistry strategies that are currently available for the discovery of selective BChE inhibitors.