The signaling pathways that mediate the anti-cancer effects of caloric restriction. (March 2019)

• Record Type: Journal Article
• Authors: Lu, Yiyi; Tao, Fengxing; Zhou, Meng-Tao; Tang, Kai-Fu
• Is Part Of: Pharmacological research. Volume 141(2019)
• Page Start: 512
• Page End: 520
• Publication Date: 2019-03
• Subjects: ALDOA aldolase A -- AMPK AMP-activated protein kinase -- APC anaphase-promoting complex -- CR Caloric restriction -- CtIP C-terminal binding protein interacting protein -- DNA-PK DNA-dependent protein kinase -- DSBs double-strand breaks -- ERRα estrogen related receptor alpha -- FOXO forkhead box O -- GLUD1 glutamate dehydrogenase 1 -- GOT2 glutamate oxaloacetate transaminase 2 -- GSK-3 glycogen synthase kinase 3 -- HIF1α hypoxia-inducible factor-1α -- IGF-1 insulin-like growth factor-1 -- IGF1R insulin-like growth factor 1 receptor -- IGFBP IGF-binding protein -- IRS-1 insulin receptor substrate-1 -- MAPK mitogen-activated protein kinase -- MDM2 mouse double minute 2 homolog -- MEFs mouse embryonic fibroblasts -- mTORC mammalian target of rapamycin complex -- NF-κB nuclear factor kappa-light-chain-enhancer of activated B cells -- NHEJ nonhomologous end-joining -- OGG1 8-oxoguanine-DNA glycosylase 1 -- PDK1 3′-phosphoinositide-dependent kinase-1 -- PI3K phosphoinositide 3-kinase -- PKM2 pyruvate kinase M2 -- ROS reactive oxygen species -- TBP TATA box-binding protein; Caloric restriction -- DNA damage -- Cancer -- Signaling pathway; Pharmacology -- Periodicals; Pharmacology -- Periodicals; Research -- Periodicals; Médicaments -- Recherche -- Périodiques; Pharmacologie -- Périodiques; 615.105
• DOI: 10.1016/j.phrs.2019.01.021
• Languages: English
• ISSNs: 1043-6618

Abstract

Graphical abstract: Abstract: Caloric restriction (CR) has been shown to promote longevity and ameliorate aging-associated diseases, including cancer. Extensive research over recent decades has revealed that CR reduces IGF-1/PI3K/AKT signaling and increases sirtuin signaling. We recently found that CR also enhances ALDOA/DNA-PK/p53 signaling. In the present review, we summarize the molecular mechanisms underlying the modulation of the IGF-1/PI3K/AKT pathway, sirtuin signaling, and the ALDOA/DNA-PK/p53 pathway by CR. We also summarize the evidence concerning the roles of these signaling pathways in carcinogenesis, and discuss how they are regulated by CR. Finally, we discuss the crosstalk between these signaling pathways.