Protective effects of curcumin against ischemia-reperfusion injury in the liver. (March 2019)

• Record Type: Journal Article
• Authors: Bavarsad, Kowsar; Riahi, Maryam Matbou; Saadat, Saeideh; Barreto, George; Atkin, Stephen L.; Sahebkar, Amirhossein
• Is Part Of: Pharmacological research. Volume 141(2019)
• Page Start: 53
• Page End: 62
• Publication Date: 2019-03
• Subjects: Ischemia-reperfusion injury -- Curcumin -- Liver -- Transplantation; Pharmacology -- Periodicals; Pharmacology -- Periodicals; Research -- Periodicals; Médicaments -- Recherche -- Périodiques; Pharmacologie -- Périodiques; 615.105
• DOI: 10.1016/j.phrs.2018.12.014
• Languages: English
• ISSNs: 1043-6618

Abstract

Graphical abstract: Abstract: Liver ischemia/reperfusion (I/R) injury is a major complication of hepatic surgery and transplantation. It is one of the leading causes of morbidity and mortality because of post-surgery hepatic dysfunction. Several studies have suggested different mechanisms are involved in the pathogenesis of I/R injury in the liver that includes oxidative stress, inflammation, mitochondria dysfunction, liver Kupffer cells (KCs) activation, vascular cell adhesion molecule overexpression, and facilitation of polymorphonuclear neutrophil injury. Curcumin is a natural product extracted from Curcuma longa that is known to suppress these pathways and as a result reduces liver ischemia-reperfusion injury. This paper gives an overview of the protective effects of curcumin against I/R injury in the liver and discusses the studies that have linked biological functions of curcumin with liver I/R injury improvement.