Biopolymer-hydrophobic drug fibers and the delivery mechanisms for sustained release applications. (March 2019)

• Record Type: Journal Article
• Authors: Valério, Alexsandra; Mancusi, Erasmo; Ferreira, Fabienne; Guelli Ulson de Souza, Selene M.A.; de Souza, Antônio Augusto Ulson; González, Sergio Yesid Gómez
• Is Part Of: European polymer journal. Volume 112(2019)
• Page Start: 400
• Page End: 410
• Publication Date: 2019-03
• Subjects: Drug delivery -- Electrospun fibers -- PCL -- Hydrophobic drug -- Drug delivery mechanisms -- Sustained release; Polymers -- Periodicals; Polymerization -- Periodicals; Polymères -- Périodiques; Polymérisation -- Périodiques; Polymerization; Polymers; Periodicals; Electronic journals; 547.705
• DOI: 10.1016/j.eurpolymj.2019.01.016
• Languages: English
• ISSNs: 0014-3057

Abstract

Graphical abstract: Highlights: A novel approach to design responsive drug delivery systems is presented. Drug delivery governed by the interaction of the polymer, active agent and water. Drug release modeled through 2 mechanisms, limited diffusion and Fickian diffusion. The drug delivery profiles in this work are smooth, gradual, sustained and complete. Abstract: Forthcoming drug delivery devices are systems designed to have delivery profiles significantly changed by an external stimuli or conditions. The translation of stimuli-responsive drug-delivery systems from the lab to the bedside is not straightforward, mainly by their usually sophisticated designs. Herein, we propose and detail a simple drug delivery design approach, exploiting the water uptake and diffusion phenomena in fibers containing hydrophilic antibacterial agents, to achieve a sustained and complete release. The manufactured delivery systems were evaluated assessing both, antibiofilm potential and delivery mechanisms. Our analysis, let us to distinctly separate the release profiles in two regions, each one dominated by a different mechanism. Within the first period of delivery, the release is dominated by a limited diffusion mechanism that cannot be described by a Fickian model, only after the ratio of mass delivered reach about 70%, the release behavior change and diffusion becomes the dominant mechanism. For the last range, the diffusion coefficients have been estimated, showing independency from initial concentrations. The switch and the mechanisms dominance are explained through a fiber mesh-like behavior activated by the water-uptake.