New hydroperoxybriarane diterpenoids from the octocoral Briareum violaceum. Issue 11 (15th March 2019)

• Record Type: Journal Article
• Authors: Yao, Jia-Wen; Chi, Wei-Chiung; Xu, Jing-Hao; Lee, Gene-Hsiang; Chiang, Michael Y.; Peng, Bo-Rong; Lin, Nai-Cheng; Hu, Chiung-Chin; Fang, Lee-Shing; Li, Guo-Qiang; Chang, Yu-Chia; Hwang, Tsong-Long; Sung, Ping-Jyun
• Is Part Of: Tetrahedron. Volume 75:Issue 11(2019)
• Page Start: 1510
• Page End: 1516
• Publication Date: 2019-03-15
• Subjects: Briareum violaceum -- Briaviolide -- Brianthein W -- Superoxide anion; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tet.2019.01.069
• Languages: English
• ISSNs: 0040-4020

Abstract

Abstract: A known briarane, brianthein W (1 ), along with four new hydroperoxybriaranes, briaviolides R–U (2 –5 ), have been obtained from the octocoral Briareum violaceum . The absolute configuration of1 was determined by X-ray analysis for the first time and the structures of briaranes2 –5 were established by spectroscopic methods. Bioactivity study showed that briarane3 decreased the production of superoxide anions from human neutrophils. Graphical abstract: Image 1