Isolated Central Nervous System Vasculitis Associated with Antiribonuclear Protein Antibody. (14th July 2011)

• Record Type: Journal Article
• Authors: Awad, Amer M.; Stevenson, Mathew
• Other Names: Atri Alireza Academic Editor.; Banerjee Tapas Kumar Academic Editor.; Narita Yugo Academic Editor.
• Is Part Of: Case reports in neurological medicine. Volume 2011(2011)
• Publication Date: 2011-07-14
• Subjects: Neurology -- Periodicals; Nervous system -- Diseases -- Periodicals; Neurology; Nervous System Diseases; Nervous system -- Diseases; Neurology; Electronic journals; Periodicals; Periodicals; 616.8
• DOI: 10.1155/2011/495201
• Languages: English
• ISSNs: 2090-6676

Abstract

Abstract : We describe the case of a young woman who was referred to a tertiary care center with unexplained subacute progressive encephalopathy preceded by long-standing severe headaches. Her extensive workup was remarkable for abnormal intracranial angiography suggestive of small- and medium-vessel vasculitis, persistently elevated protein in the cerebrospinal fluid and persistently high titers of antiribonuclear protein antibody. The patient showed a modest response to intravenous high-dose steroids. We propose that the patient's neurologic disease is secondary to immune-mediated central nervous system vasculitis, possibly as an initial manifestation of mixed connective tissue disease.