Intraoperative Consultation and Macroscopic Handling: The International Society of Urological Pathology (ISUP) Testicular Cancer Consultation Conference Recommendations. (June 2018)

• Record Type: Journal Article
• Authors: Verrill, Clare; Perry-Keene, Joanna; Srigley, John R.; Zhou, Ming; Humphrey, Peter A.; Lopez-Beltran, Antonio; Egevad, Lars; Ulbright, Thomas M.; Tickoo, Satish K.; Epstein, Jonathan I.; Compérat, Eva; Berney, Daniel M.
• Is Part Of: American journal of surgical pathology. Volume 42:Number 6(2018)
• Publication Date: 2018-06
• Subjects: testis -- germ cell tumor -- guidelines; Pathology, Surgical -- Periodicals; 617.0705
• DOI: 10.1097/PAS.0000000000001049
• Languages: English
• ISSNs: 0147-5185

Abstract

Abstract : The International Society of Urological Pathology held a conference on issues in testicular and penile pathology in Boston in March 2015, which included a presentation by the testis macroscopic features working group. The presentation focused on current published guidance for macroscopic handling of testicular tumors and retroperitoneal lymph node dissections with a summary of results from an online survey of members preceding the conference. The survey results were used to initiate discussions, but decisions on practice were made by expert consensus rather than voting. The importance of comprehensive assessment at the time of gross dissection with confirmation of findings by microscopic assessment was underscored. For example, the anatomic landmarks denoting the distinction of hilar soft tissue invasion (pT2) from spermatic cord invasion (pT3 category) can only be determined by careful macroscopic assessment in many cases. Other recommendations were to routinely sample epididymis, rete testis, hilar soft tissue, and tunica vaginalis in order to confirm macroscopic invasion of these structures or if not macroscopically evident, to exclude subtle microscopic invasion. Tumors 2 cm or less in greatest dimension should be completely embedded. If the tumor is >2 cm in greatest dimension, 10 blocks or a minimum of 1 to 2 additional blocks per centimeter should be taken (whichever is greater).