Technical Pitfall in 68Ga–Prostate Specific Membrane Antigen Imaging: Altered Biodistribution Caused by Free 68Ga-Citrate Due to Radiolysis Showing Increased Vascular Activity. (June 2018)

• Record Type: Journal Article
• Authors: Hod, Nir; Anconina, Reut; Levin, Daniel; Ezroh Kazap, Dina; Lantsberg, Sophie
• Is Part Of: Clinical nuclear medicine. Volume 43:Number 6(2018)
• Publication Date: 2018-06
• Subjects: 68Ga-citrate -- 68Ga-PSMA -- altered biodistribution -- PET/CT -- radiolysis -- technical pitfall; Nuclear medicine -- Periodicals; Radioisotope scanning -- Periodicals; Nuclear Medicine -- Periodicals; 616.07575
• DOI: 10.1097/RLU.0000000000002087
• Languages: English
• ISSNs: 0363-9762

Abstract

Abstract : Abstract: As with any new molecular imaging modality, accurate characterization of abnormalities on 68 Ga-PSMA PET/CT imaging can be accomplished only if one is aware of the normal distribution pattern, physiological variants, and potential sources of false imaging findings. Altered biodistribution can have a significant impact on scan interpretation. Presented here is a rare case in which radiopharmaceutical radiolysis occurred causing excessive free 68 Ga-citrate showing as an increased vascular activity. As 68 Ga-PSMA PET/CT imaging is a relatively new imaging technique, it is important to be aware of such a potential technical pitfall in clinical practice in order to prevent scan misinterpretation.