Ageing effect on 18F-DOPA and 123I-MIBG uptake: a cross-sectional study. Issue 6 (June 2018)

• Record Type: Journal Article
• Authors: Chiaravalloti, Agostino; Barbagallo, Gaetano; Ricci, Maria; Sannino, Pasqualina; Karalis, Georgios; Ursini, Francesco; Schillaci, Orazio
• Is Part Of: Nuclear medicine communications. Volume 39:Issue 6(2018:Jun.)
• Publication Date: 2018-06
• Subjects: ageing -- 18F-DOPA -- 123I-MIBG -- PET -- PET/CT; Nuclear medicine -- Periodicals; 616.07575
• DOI: 10.1097/MNM.0000000000000835
• Languages: English
• ISSNs: 0143-3636

Abstract

Abstract : Background: The aim of this study was to investigate the relationship between age and uptake of fluorine-18-L-dihydroxyphenylalanine ( 18 F-DOPA) in the brain and myocardial uptake of iodine-123-metaiodobenzylguanidine ( 123 I-MIBG) in normal adult participants. Participants and methods: To this end, a total of 72 healthy participants were enroled. Of these, 37 individuals (male, 21; female, 16; mean age: 60±12 years; age range: 38–85 years) underwent 18 F-DOPA PET/CT, whereas 35 individuals (male, 19; female, 16; mean age: 61±17 years; age range: 17–87 years) underwent 123 I-MIBG scintigraphy. For 18 F-DOPA PET/CT, regions of interest were placed on the caudate nucleus, globus pallidus and putamen by means of the WFU Pickatlas tool implemented in SPM8 and further analysed after a normalization process. For 123 I-MIBG scintigraphy, regions of interest were set over the upper mediastinum and a heart-to-mediastinum count ratio was calculated. The relation between age and normalized 18 F-DOPA values or heart-to-mediastinum ratio values was examined using correlation analysis of variance and Pearson's correlation coefficient. Results: We did not find any significant relationship between age and 18 F-DOPA and 123 I-MIBG uptake, respectively. Conclusion: Our findings suggest that both brain 18 F-DOPA PET/CT and cardiac 123 I-MIBG scintigraphy represent age-independent biomarkers whose analyses of quantitative uptake may not require adjustment for patients' age.