Diffusely Metastasized Adenocarcinoma Arising in a Mucinous Carcinoid of the Ovary: A Case Report. (May 2018)

• Record Type: Journal Article
• Authors: Van Rompuy, Anne-Sophie; Vanderstichele, Adriaan; Vergote, Ignace; Moerman, Philippe
• Is Part Of: International journal of gynecological pathology. Volume 37:Number 3(2018)
• Publication Date: 2018-05
• Subjects: Mucinous carcinoid -- Goblet cell carcinoid -- Ovary -- Carcinoma arising in mucinous carcinoid; Gynecologic pathology -- Periodicals; Gynecology -- Periodicals; Generative organs, Female -- Diseases -- Periodicals; 618.10705
• DOI: 10.1097/PGP.0000000000000398
• Languages: English
• ISSNs: 0277-1691

Abstract

Abstract : Mucinous (goblet cell) carcinoids are a rare type of ovarian carcinoid tumors. Only a limited number of primary mucinous carcinoids of the ovary have been reported in the literature. We describe the case of a 55-year-old woman with a diffusely metastasized adenocarcinoma arising in a primary ovarian mucinous carcinoid. The differential diagnosis with a metastatic goblet cell carcinoid from the appendix or elsewhere can be very challenging. In our case, especially the immunohistochemical profile of the tumor with diffuse positivity for cytokeratin 7 and PAX8, and no expression of cytokeratin 20 and CDX2, directed us toward a primary ovarian origin. Expression of PAX8 in ovarian mucinous carcinoid has never been reported before.