Prostate-Specific Membrane Antigen–Negative Metastases—A Potential Pitfall in Prostate-Specific Membrane Antigen PET. (June 2018)

• Record Type: Journal Article
• Authors: Noto, Benjamin; Auf der Springe, Katharina; Huss, Sebastian; Allkemper, Thomas; Stegger, Lars
• Is Part Of: Clinical nuclear medicine. Volume 43:Number 6(2018)
• Publication Date: 2018-06
• Subjects: metastases -- negative -- PET/CT -- prostate cancer -- PSMA -- sensitivity; Nuclear medicine -- Periodicals; Radioisotope scanning -- Periodicals; Nuclear Medicine -- Periodicals; 616.07575
• DOI: 10.1097/RLU.0000000000002073
• Languages: English
• ISSNs: 0363-9762

Abstract

Abstract : Abstract: 68 Ga-PSMA-11 PET/CT was performed in a 74-year-old man because of biochemical recurrence of prostate cancer following radiation therapy of the prostate gland 24 months earlier. Besides focal nuclide accumulation in the prostate gland suggestive of local recurrence, PET scan revealed no further pathologic uptake. However, CT showed multiple pulmonic nodules suggestive of metastases. Thoracotomy and pathologic examination revealed the nodules to be prostate cancer metastasis. Furthermore, immunohistochemical staining with PSMA antibodies demonstrated a virtual lack of PSMA expression. This case demonstrates the possibility of PSMA-negative metastases of prostate cancer an important pitfall that should be known to physicians interpreting PSMA PET.