Noncirrhotic portal hypertension. Issue 3 (May 2018)

• Record Type: Journal Article
• Authors: Da, Ben L.; Koh, Christopher; Heller, Theo
• Is Part Of: Current opinion in gastroenterology. Volume 34:Issue 3(2018:May)
• Publication Date: 2018-05
• Subjects: ascites -- elastography -- hepatic encephalopathy -- hypertension -- liver cirrhosis -- portal; Gastroenterology -- Periodicals; 616.33
• DOI: 10.1097/MOG.0000000000000433
• Languages: English
• ISSNs: 0267-1379

Abstract

Abstract : Purpose of review: Noncirrhotic portal hypertension represents a heterogeneous group of liver disorders that is characterized by portal hypertension in the absence of cirrhosis. The purpose of this review is to serve as a guide on how to approach a patient with noncirrhotic portal hypertension with a focus on recent developments. Recent findings: Recent studies pertaining to noncirrhotic portal hypertension have investigated aetiological causes, mechanisms of disease, noninvasive diagnostic modalities, clinical characteristics in the paediatric population and novel treatment targets. Summary: Noncirrhotic portal hypertension is an underappreciated clinical entity that can be difficult to diagnosis without a healthy suspicion. Diagnosis then relies on a comprehensive understanding of the causes and clinical manifestations of this disease, as well as a careful interpretation of the liver biopsy. Noninvasive approaches to diagnosis may play a significant role moving forward in this disease. Treatment in NCPH remains largely targeted at the individual sequalae of portal hypertension.